Antimicrobial activities of chlorogenic acid and 13 main metabolites in vitro / 中草药
Rong FAN.
Chinese Traditional and Herbal Drugs
; (24): 6239-6245, 2020.
Artículo
en Zh
| WPRIM | ID: wpr-845986
Objective:
To compare with the antimicrobial activities of chlorogenic acid and its 13 main metabolites in vivo.Methods:
Main metabolites were detected by broth microdilution method against clinical isolated strains including methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), non ESBLs-producting Escherichia coli (E-), extended-spectrum β-lactamase Escherichia coli (E+), Klebsiella pneumoniae (E-/E+), Acinetobacter baumannii, and Pseudomonas aeruginosa to compare with the minimal inhibitory concentrations value of chlorogenic acid.Results:
For the most tested strains, the antibacterial activities of some major metabolites were enhanced, ranging from four to 66 times higher than chlorogenic acid. Benzoic acid, p-hydroxybenzoic acid, p-coumaric acid, dihydrocaffeic acid, and gallic acid were stronger than the other metabolites. Moreover, the antibacterial actions of dihydrocaffeic acid and gallic acid against MSSA and MRSA was increased 33-66 times respectively.Conclusion:
Some main metabolites presented more potent antibacterial activities than chlorogenic acid, and chlorogenic acid may exert antibacterial effects through some of its metabolites.
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WPRO
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