Receptor activation of curcumin on human peroxisome proliferators-activated receptors γ1 / 中草药
Xue-Mei YANG.
Chinese Traditional and Herbal Drugs
; (24): 3122-3126, 2017.
Artículo
en Zh
| WPRIM | ID: wpr-852620
Objective:
To determine whether curcumin is a natural ligand for human peroxisome proliferators-activated receptors γ1 (hPPARγ1) by measuring the combination ability and internal activity.Methods:
The combination ability was determined by radioactively labeled ligand binding experiment (RBCA), and the internal activity was estimated by trans-activation reporter gene test.Results:
The combination ability of curcumin on hPPARγ1 showed that IC50 was (8.82 ± 0.74) μmol/L, and Ki was 0.72 μmol/L. The internal activity showed that EC50 was 7.3 μmol/L and Emax was 43.3.Conclusion:
Curcumin has affinity and intrinsic activity with hPPARγ1, which suggests that curcumin may be a natural ligand of hPPARγ1.
Biblioteca responsable:
WPRO
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