@#The development of
materials science is of great significance to the
treatment of
dental pulp diseases. Poly
lactic acid glycolic
acid (PLGA) copolymer is an organic macromolecule compound that is widely used in the preparation of biomedical materials. In recent years, PLGA, as a
drug/molecular loaded system and
tissue regeneration scaffold, has shown prospects for application in the
treatment of
dental pulp diseases. This
paper will review the application of PLGA in the
treatment of
dental pulp diseases and provide a basis for its further development and utilization. The results of the
literature review show that PLGA is a
drug/molecular delivery system that is mainly used in the improvement of
pulp capping materials,
root canal disinfectant and
apexification materials. PLGA-improved
pulp capping agents can prolong the action
time of the
drug and reduce
toxicity. The modified
root canal disinfectant can realize the sustained release of
drug, make the
drug penetrate deeper into the subtle structure, and contact more widely with the pathogenic
bacteria. The modified
apexification materials can provide more convenient
administration methods for apexifixment. As a scaffold for
tissue engineering, PLGA is mainly used in the study of pulp
regeneration. The
optimization of PLGA
physical properties and action
environment can provide a more suitable microenvironment for
seed cells to proliferate and differentiate. How to utilize the advantages of PLGA to develop a more suitable material for endodontic application
needs further study.