Association study of single nucleotide polymorphism of rs284489 in the 8q22 region with primary open angle glaucoma in a Sichuan Han Chinese population / 中华实验眼科杂志
The allele distribution of rs284489 was within the HWE for both case and control groups (both at P>0.05). The difference of the minorallele-G distribution between the case group and the control group was not significant (allelic P*=0.94, OR [95% CI] **=1.01[0.83-1.23]); To further investigate the association between rs284489 and POAG, four genetic models, including model 1 (AG vs. AA), additive model 2 (GG vs.AA), dominant model (GG+ AG vs.AA), and recessive model (GG vs.AG+ AA) were applied.There was no significant difference in the four genetic models between the case and control groups (adjusted P# additive model 1 =0.26, P# additive model 2 =0.54, P# dominant model =0.50, P# recessive model =0.25); the gender difference in this study was not associated with the polymorphism of rs284489 (adjusted P#=1.00, crude OR [95% CI]=1.00[0.88-1.14], adjusted OR [95% CI]=1.00 [0.87-1.14]).
Conclusions:
rs284489 is not statistically associated with POAG in a Sichuan Han Chinesepopulation.