Biblioteca Virtual en Salud

Objective:

To explore the functional connections of the whole brain and the two hemispheres in patients with obsessive-compulsive disorder (OCD).

Methods:

Twenty-six patients with obsessive-compulsive disorder(patients group) and thirty-seven healthy controls matched in gender, age and education(control group) were enrolled.All the participants accepted the resting-state functional magnetic resonance (rs-fMRI) scan.Based on DPABI and REST software, degree centrality (DC) and voxel - mirrored homotopic connectivity (VMHC) approaches were used to explore the pattern of functional connection in OCD.

Results:

Compared with the control group, the DC values in the right posterior cerebellar lobe(MNI x, y, z=45, -87, -12), left precentral gyrus(MNI x, y, z=-54, 9, 39), left inferior parietal lobule(MNI x, y, z=-48, -51, 42), right anterior cingulate cortex(MNI x, y, z=3, 18, 48) were significantly higher( t values were 5.75, 5.26, 5.28 and 5.16, respectively), and the DC values in the left inferior frontal gyrus(MNI x, y, z=-36, 9, 30) were significantly lower( t value was -6.65) in patients group.The VMHC values in bilateral posterior cerebellar lobe(MNI x, y, z=±51, -69, -33), bilateral inferior parietal lobule(MNI x, y, z=±48, -51, 54), bilateral anterior cingulate cortex(MNI x, y, z=±3, 21, 45)in patients group were significantly higher that those in control group( t values were 5.19, 5.19, 5.02, 5.02, 5.15 and 5.15, respectively). The DC and VMHC values in patients group were not significantly correlated with clinical symptoms(-0.23< r<0.19, P>0.05).

Conclusion:

OCD patients have abnormal connections between key brain network nodes and relevant brain regions, and functional connections have increased among multiple cerebral hemispheres.