Objective: To analyze the clinical data of 203 discharged
patients with corona
virus disease 2019(COVID-19), and to investigate the predictors for the severe cases.
Methods: Confirmed COVID-19 cases hospitalized at Zhongnan
Hospital of Wuhan
University from January 1 to February 1, 2020 were consecutively enrolled,
who were divided into severe group and non-severe group.The clinical data of enrolled
patients were collected and the clinical manifestations,
laboratory results, imaging,
treatments and
prognosis of
patients in the two groups were analyzed. Mann-Whitney U rank sum test and
chi-square test were used for
statistical analysis .
Results: A total of 203 discharged
patients with COVID-19 were enrolled. The common clinical manifestations included
fever (89.2%, 181/203), dry
cough (60.1%, 122/203),
chest distress (35.5%, 72/203),
shortness of breath (29.1%, 59/203)and
myalgia or
arthralgia (26.6%, 54/203). The
time from
disease onset to
hospital admission was 5.8 days (1.0 to 20.0 days). Among 203 enrolled
patients , 107(52.7%) were divided into severe group and 96(47.3%) were non-severe group. The age in severe group was 60 years (23 to 91 years), which was significantly older than non-severe group (47 years (20 to 86 years)), the difference was statistically significant ( Z=-6.12, P<0.01). There were 63.6%(68/107)
patients in severe group with at least one underlying
disease , which was significantly more than non-severe group (20.8% (20/96)), the difference was statistically significant ( χ2=37.60, P<0.01). The proportions of
patients with increased
white blood cells , decreased
lymphocytes and
albumin , elevated
alanine aminotransferase ,
aspartate aminotransferase ,
creatinine ,
lactic acid dehydrogenase ,
creatine kinase ,
fasting blood glucose , D-dimer,
erythrocyte sedimentation rate ,
C-reactive protein ,
interleukin-6 , and
procalcitonin in severe group were all higher. On admission, 172
patients (84.7%) had bilateral patchy shadows or ground
glass opacity in the
lungs on
chest imaging study, 20(9.9%) presented
pleural effusion . Fifty-five cases (27.1%) showed progressions of
lung lesions on computed
tomography (CT) rescan at an average interval of five days. Among 203
patients , 123(60.6%) were given
oxygen therapy upon admission, 107(52.7%) were given short-term
glucocorticoid therapy , and 131(64.5%) received
antiviral therapy ; and 26(12.8%) died. The
hospital stay was 11.0 days (1.0 to 45.0 days).
Conclusions: Fever is the most common symptoms in COVID-19
patients .
Elderly and
patients with underlying
diseases are
risk factors for progression to severe cases. The
elderly patients should be strengthened early
monitoring , paid
attention to the control of underlying
diseases , and reduce the occurrence of critical
diseases .