Objective: To compare the
prognosis of pancreatic
head cancer , uncinate process
cancer and pancreatic
neck cancer patients after undergoing
pancreatoduodenectomy .
Methods: The clinical data and follow-up data of 71
pancreatic cancer patients undergoing
pancreatoduodenectomy in the First Affiliated
Hospital of Xinjiang Medical
University were analyzed retrospectively, Kaplan Meier
method was used to compare the
survival of postoperative
patients . COX proportional
risk model was used to analyze the
survival of three groups of
tumor .
Results: In
pancreatic cancer patients , uncinate process
cancer and pancreatic
neck cancer had more frequent vascular invasion, higher
lymph node metastasis rate and lower R 0 resection rate than pancreatic
head cancer (all P<0.05). Multivariate COX suggested that vascular invasion ( P=0.018),
lymph node metastasis ( P=0.001),
tumor site ( P=0.022 in uncinate process, P=0.000 in pancreatic
neck ) and R 0 resection ( P=0.000) were independent
risk factors for
prognosis . For pancreatic
head cancer the 1-year
recurrence rate was 43.8%, 3-year
survival rate was 28.1%, median
survival time was 20.0 months (95% CI 15.565-24.435). For uncinate process
cancer 1-year
recurrence rate was 61.5%, 3-year
survival rate was 15.4%, median
survival time was 14.0 months (95% CI 9.003-18.997) respectively.That was 69.2%, 7.7% and 10.0 months (95% CI 5.303-14.697) respectively for pancreatic
neck cancer .
Conclusion: Compared with pancreatic
head cancer , uncinate process
cancer and pancreatic
neck cancer are associated with poorer
prognosis because of frequent early vascular invasion, low R 0 resection rate and early local
recurrence .