Comparison on Pharmacodynamics of Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma from Four Different Sources on Rats with Qi Deficiency / 中国实验方剂学杂志
A model of spleen-Qideficiency was induced in rats by diet and overwork.The rats are given different suspensions of A.japonica, A.chinesis, A.coreana, A.lancea and Atractylodis Macrocephalae Rhizoma To test the indicators of the digestive system, immune system and antioxidantenzyme system related to spleendeficiency.Compare the similarities and differences between Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma from four different sources.
Result:
All the drug-administered groups can increase the levels of γ interferon (IFN-γ), gastric secrete element(GAS),serumamylase (AMS) and catalase(CAT) in rats with spleen-deficiencysyndrome,in addition to the CAT index, the other indicators of the A. coreana, A.japonica, and A.lancea were significantly increased(P<0.05). The MTL content of the A.chinesis, A.lancea, A.coreana and A.japonica increased and was significant(P<0.05). The SDH content of A.japonica.and A.chinesis increased, and the difference was not significant.The increase of GSH-Px in the A.chinesis is significant(P<0.05). All the drug-administered groups can reduce the content of IgG, TNF-α and MDA in rats with spleendeficiency and deficiencysyndrome. Among them, the IgG content of the A.chinesis. and the A.lancea was significantly decreased(P<0.05). The content of TNF-α in A.japonica group was significantly decreased(P<0.05). The content of MDA in the A.chinesis, the A.lancea, the A.coreana,the A.japonica and the Atractylodis Macrocephalae Rhizoma were significantly decreased(P<0.05).The decrease of IL-6 in the A.lancea was significant(P<0.05).