Objective: To observe the effect of modified Banxia Xiexintang on
depression during
perimenopause , in order to study itseffecton
5-hydroxytryptamine (
5-HT ) and proinflammatory factors.
Method: One hundred and thirty-nine
patients were randomly divided into
control group (69 cases) and
observation group (70 cases) by random number table.
Patients in
control group got tibolone
tablets , 2.5 mg/
time , 1
time /day, and
paroxetine hydrochloride tablets , 20 mg/
time , 1
time /day.In addition to the
therapy in
control group ,
patients in
observation group were added with modified Banxia Xiexintang, 1
dose /day.The
course of
treatment was 8 weeks.And before and
after treatment , Hamilton
depression scale for-17 items (HAMD-17), Zung's
self -rating
depression scale (SDS), hamilton
anxiety scale (HAMA), improvement Kupperman(KI),
liver depression and
spleen deficiency syndrome ,
menopause -specific
quality of life questionnaire (MENQOL) and
treatment emergent symptom scale (TESS) were scored, and levels of
5-HT ,
rain -derived
neurotrophic factor (
BDNF ),
interleukin-1 β (
IL-1 β) and
tumor necrosis factor -α (TNF-α) were detected.
Result: After treatment , scores of HAMD-17 and SDS in
observation group were lower than those in
control group (P<0.01). And the effect on trea
depression in
observation group was better than that in
control group (Z=2.074, P<0.05). The degree of
depression in
observation group was ligher than that in
control group (Z=2.157, P<0.05). And scores of HAMA, KI and
liver depression and
spleen deficiency syndrome were lower than those in
control group (P<0.01). The severity of perimenopausal
syndrome was ligher than that in
control group (Z=2.046, P<0.05). And scores of vasomotor symptoms and psychological symptoms of MENQOL scale and the total scores were lower than those in
control group (P<0.05). Levels of
5-HT and
BDNF were higher than those in
control group (P<0.01), while levels of
IL-1 β, TNF-α and TESS were lower than those in
control group (P<0.01).
Conclusion: In addition to theroutine western
medicine , modified Banxia Xiexintang can alleviate the severity of
depression , release the symptoms of
depression ,
anxiety and perimenopausal syudrome(PMS), improve the
quality of life , inhibit pro-inflammatory factors, and enhance the expressions of
5-HT and
BDNF , with no
adverse event .