Objective: To discuss the
clinical efficacy of Yixinshu
capsule for viral
myocarditis (VMC) with
deficiency of
Qi and Yin, and to investigate its
antioxidant and anti-inflammatory effect.
Method: One hundred and thirty-two
patients were randomly divided into
control group (66 cases) and
observation group (66 cases) by random number table.
Patients in two group got comprehensive
treatment of Western
medicine , i.e.
intravenous drip of
creatine phosphate injection for 14 days, 1 g/
time , 1
time /day.
Coenzyme Q10
capsule , 1 grain/
time , 3 times/day after
meals .
Trimetazidine dihydrochloride tablets , 1
tablet /
time , 3 times/day during
meals . And
critically ill patients got
intravenous drip of
dexamethasone sodium phosphate injection for 14 days, 10-20 mg/
time , 1
time /day. The
control group took Wenxin granules orally,One bag at a
time ,3 times/day.
Patients in
observation group additionally got Yixinshu
capsule , 3 grains/
time , 3 times/days. The
courses of
treatment were 8 weeks in both groups. The
serum troponin I (cTnI) and
creatine phosphokinase (CK-MB) were monitored, and
after treatment , the recovery rates of cTnI, CK-MB were recorded. Before and
after treatment , the
electrocardiogram was observed and the recovery rate
after treatment was recorded. Before and
after treatment , the scores of
deficiency of
Qi and Yin were graded, and levels of
creatine phosphokinase (CPK),
hydroxybutyrate dehydrogenase (HBDH),
lactate dehydrogenase (LDH),
aspartate aminotransferase (AST),
superoxide dismutase (SOD),
malondialdehyde (MDA),
glutathione peroxidase (GSH-Px),
interferon -γ (IFN-γ),
interleukin-10 (
IL-10 ),
IL-17 and IL-35 were detected.
Echocardiography , left
ventricular ejection fraction (LVEF), cardiac index (CI), and maximum velocity values between early and late diastolic (E/A) were detected.
Result: In the
analysis of rank sum test,
clinical efficacy in
observation group was better than that in
control group (Z=2.151, P<0.05). Recovery rates of cTnI, CK-MB and
electrocardiogram in
observation group were 82.26% (51/62), 90.32% (56/62) and 80.65% (50/62), higher than 65.00% (39/60), 73.33% (44/60) and 63.33% (38/60) in
control group (P<0.05). Levels of
serum cTnI, CK-MB, CPK, HBDH, LDH, AST, MDA, IFN-γ and
IL-17 were lower than those in
control group (P<0.01), while levels of LVEF, CI, E/A, SOD, GSH-Px,
IL-10 and IL-35 were higher than those in
control group (P<0.01).
Conclusion: On the basis of comprehensive anti-
infection treatment , Yixinshu
capsule can additional protect
myocardium by anti-inflammatory and
antioxidant effect , reduce myocardial
enzyme , promote the recovery of
ECG and cardiac
enzyme , improve cardiac function and improve the effect of clinical
treatment .