Objective@#To analyze the relationship between
thrombin activatable fibrinolysis inhibitor ( TAFI ) and
coronary heart disease ( CHD ), and to provide evidence for the prevention of CHD. @*
Methods@#The
patients with CHD in Fushun Central
Hospital in Liaoning Province were selected as the case group, the
patients without CHD in the same
hospital and period were selected as the
control group. The demographic information and clinical examination results (
serum TAFI,
lipid,
glucose, etc. ) were collected to analyze the
association between TAFI and CHD by
logistic regression models.The multivariate
logistic regression analysis was used to explore the relationship between TAFI and CHD.@*Results@#There were 222 cases, including 100 cases of
stable angina, 44 cases of
unstable angina and 78 cases of acute
myocardial infarction, and 222 controls. The median ages of cases and controls were 62 and 57 years old. The results of multivariate
logistic regression analysis showed that
serum TAFI>22.88 μg/mL ( P75 of controls ) was associated with the
risk of CHD ( OR=1.619, 95%CI 1.011-2.593 ),
unstable angina ( OR=2.917, 95%CI 1.433-5.939 ) and acute
myocardial infarction ( OR=2.626, 95%CI 1.007-6.847 ). @*Conclusion@#The high level of TAFI is related to CHD,
unstable angina and acute
myocardial infarction.