Objective@#To understand the
survival status and influencing factors of
HIV/
AIDS patients with
highly active antiretroviral therapy (
HAART ) among
drug users in Yili Prefecture, Xinjiang from 2005 to 2019, so as to provide references for reducing
AIDS mortality. @*
Methods @#The demographic information, clinical stage, baseline CD4+
T lymphocyte ( CD4 ) level and
treatment status of
HIV/
AIDS patients with
HAART in Yili Prefecture from 2005 to 2019 were collected through
AIDS Antiretroviral
Therapy Information System. The
survival rate was calculated by the
life table method. The influencing factors for
survival time were analyzed by Cox proportional
hazard regression model.@*Results@#Totally 1 935
patients were recruited, the median age receiving
HAART was 37 years old and the median
CD4 counts was 293/μL. The
cumulative survival rates at 1, 5, 7 and 10 years were 97%, 78%, 73%, and 66%, respectively. The multivariate Cox proportional
hazards regression analysis showed that the
patients with
body mass index of 18.5-<28.0 kg/m2 ( HR 0.391-0.656, 95%CI 0.234-0.958 ), baseline CD4>200/μL ( HR 0.354-0.667, 95%CI 0.232-0.841 ) , or missed medication in the last 7 days ( HR=0.009, 95%CI 0.001-0.061 ) had lower
risk of
death; the
patients with
WHO clinical stage of Ⅱ-Ⅳ ( HR 1.479-2.311, 95%CI 1.004-3.288 ) or
treatment delay ≥1 years ( HR 1.287-1.388, 95%CI 1.029-1.826 ) had higher
risk of
death. @*Conclusions@#The 5-year
cumulative survival rate of
HIV/
AIDS patients with
HAART in Yili Prefecture is 78%.
Body mass index, baseline CD4 level,
WHO clinical stage,
treatment delay and missed medication in last 7 days were the influencing factors for
survival time.