OBJECTIVE@#To analyze the
risk factors affecting
hemorrhagic cystitis(HC) after allogeneic
hematopoietic stem cell transplantation(allo-HSCT).@*
METHODS@#The clinical data of 153
patients underwent allogeneic
hematopoietic stem cell transplantation in the First Affiliated
Hospital of Xi'an Jiaotong
University from January 2010 to December 2018 were selected and retrospectively analyzed. The
incidence, median
time and
treatment outcome of HC should be observed.
Multivariate analysis was used to observe the
risk factors of HC in
patients, including
sex, age,
diagnosis,
disease status before
transplantation,
transplantation type, ATG and CTX in the pretreatment scheme,
stem cell source,
neutrophil and
platelet implantation
time; CMV,
EBV and BKV
infection, and acute
graft-versus-host disease(aGVHD).@*RESULTS@#Among 153
patients underwent allogeneic
hematopoietic stem cell transplantation, 25 (16.34%)
patients had HC, the median occurance
time was 31 days, all
patients achieved complete remission
after treatment, no
bladder irritation and
bladder contracture were left. The results of univariate and multivariate
Logistic regression analysis showed that the type of
transplantation, ATG, CMV
viremia before
treatment, aGVHD (r=1.036, 3.234, 3.298 and 2.817, respectively) were the independent
risk factors of HC.@*CONCLUSION@#The urinary BKV detections in the
patients with HC are positive, mainly occured during the period from day +13 to days +56. HLA
haplotype, pretreatment including ATG, and CMV
viremia, and aGVHD are the independent
risk factors for HC after allo-HSCT.