BACKGROUND@#The pulmonary
microbiome is closely related to the occurrence of
pulmonary diseases. The
morbidity and
mortality of
lung cancer are relatively high in the world. It has been confirmed that
lung microecology changes in
lung cancer patients compared with healthy individuals. Furthermore, the abundance of some bacterial species shows obvious changes, suggesting their potential use as a microbial marker for the
detection of
lung cancer. The composition of the pulmonary
microbiome in
patients with different histological types of
lung cancer has not been determined. We aim to study the correlation and difference of
microbiome between different histological types of
lung cancer.@*
METHODS@#Illumina HiSeq
high-throughput sequencing technology was used to sequenced the 16S
rDNA V3-V4 region of bacterial in
sputum samples of
patients with advanced
lung cancer.@*RESULTS@#It was found that
Streptococcus,
Neisseria and
Prevotella were the main
bacteria of
lung cancer patients. Advantage bacterium group differ between different histological types of
lung cancer.
Adenocarcinoma (AD) group was dominated by
Streptococcus and
Neisseria, followed by
Veillonella.
Small cell lung cancer (SCLC) group was dominated by
Neisseria, followed by
Streptococcus.
Squamous carcinoma (SCC) group was dominated by
Streptococcus, followed by
Veillonella. Combined
small cell lung cancer (C-SCLC) group was dominated by
Streptococcus, followed by
Prevotella.@*CONCLUSIONS@#The pulmonary bacterial
microbiome of
lung cancer of different histological types is different. This experiment enrichs the pulmonary bacterial
microbiome data of
lung cancer and fills the gap of pulmonary
microbiome of
small cell lung cancer.