The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin
Baode SHEN; Chengying SHEN; Weifeng ZHU; Hailong YUAN.
Acta Pharmaceutica Sinica B
; (6): 978-988, 2021.
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| WPRIM | ID: wpr-881179
In this study, self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid nanocrystals (QT-HNCs) with diameter around 280 nm (QT-HNCs-280) and 550 nm (QT-HNCs-550) following oral and intravenous administration and the contribution of integral nanocrystals to oral bioavailability enhancement of QT was estimated by comparing the absolute exposure of integral QT-HNCs and total QT in the liver. Results showed that QT-HNCs could reside
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