Ovarian cancer has the highest mortality rate among gynecologic
malignancies in
developed countries. Most
women present with advanced
disease and require a combination of
surgery and
chemotherapy. One
patient presented with recurrent
ovarian cancer was initially treated with
taxol and
platinum-based compounds. Although response to these agents occurred,
tumor progression was evident by elevated CA 125 levels and CT findings after a period of 4 months. This
patient was then treated with
topotecan and exhibited a response and stopped
therapy.
Topotecan exhibited activity in this
patient with
ovarian cancer resistent to both
platinum and
paclitaxel. We
report a case of advanced
ovarian cancer which was treated with
topotecan after
taxol-
cisplatin treatment failed.