A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine
Haiyu XU; Yanqiong ZHANG; Ping WANG; Junhong ZHANG; Hong CHEN; Luoqi ZHANG; Xia DU; Chunhui ZHAO; Dan WU; Feng LIU; Hongjun YANG; Changxiao LIU.
Acta Pharmaceutica Sinica B
; (6): 1379-1399, 2021.
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| WPRIM | ID: wpr-888810
Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics (PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes
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