With the advent of checkpoint inhibitors, it has opened up opportunities for numerous
cancer patients. However, as is the case with every
treatment,
complications need to be weighed. Gastrointestinal
adverse effects, such as
diarrhea and
colitis are well-known
complications for checkpoint inhibitors. In severe cases,
colitis-induced colonic perforation may occur with an estimation of 1.0% to 1.5% in anti-CTLA-4
antibodies. However, only a handful of cases of such devastating
complications have been reported in anti-PD-1
antibodies such as pembrolizumab and
nivolumab. We here
report a case of
intestinal perforation in a
patient treated with
nivolumab.