Enuresis is intermittent
urinary incontinence during
sleep at night in
children aged 5 years or older. The main pathophysiology of
enuresis involves nocturnal
polyuria, abnormal
sleep arousal, and low functional
bladder capacity. In rare cases,
enuresis is an early symptom of endocrine disorders such as diabetes or
thyroid disorders. Herein, we
report a case of a 12-year-old
girl with
enuresis as a rare initial presentation of Graves’
disease. She complained of
nocturnal enuresis from a month before visiting our clinic. She also complained of urinary frequency,
headache, and
weight loss. On
physical examination, she had
tachycardia,
intention tremors, and a diffuse
goiter on her anterior
neck with bruit on
auscultation. Her
thyroid function test results revealed
hyperthyroidism, and Graves’
disease was diagnosed as the
thyroid stimulating hormone receptor autoantibody was positive.
After treatment for Graves’
disease with
methimazole, symptoms of
enuresis resolved within 2 weeks as she became clinically and biochemically euthyroid. In
children with
secondary enuresis, Graves’
disease should be considered as a
differential diagnosis, and signs of
hyperthyroidism should be checked for carefully.