Irritable bowel syndrome (IBS) and functional
dyspepsia (FD) are common
functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting
patients. These 2 disorders overlap with each other frequently. The pathogenesis of IBS or FD is complicated and multi-factors related, in which infectious or non-infectious
inflammation and local or systemic
immune response play significant
roles. There are few studies focusing on the mechanism of
inflammation in
patients with overlap
syndrome of
irritable bowel syndrome and functional
dyspepsia (IBS-FD). This
review focuses on current advances about the
role of
inflammation in the pathogenesis of IBS and FD and the possible mechanism of
inflammation in IBS-FD.