Lung cancer is a malignant
tumor with high
incidence and high
mortality, posing a great threat to
human health. Neovascularization may be one of the important mechanisms of
lung cancer. The growing
lung cancer cells can obtain necessary
nutrients from the newly formed
blood vessels, thereby causing the spread and
metastasis of
lung cancer. Nowadays,
anti-angiogenic drugs are commonly used in western
medicine in addition to
surgery,
radiotherapy,
chemotherapy, and
immunotherapy. However, the resulting adverse reactions such as
thrombosis,
hypertension,
diarrhea, and
cardiotoxicity have seriously affected the
quality of life of
patients. As the recognition of
angiogenesis deepens, the selection of
lung cancer treatment options has become a
research hotspot and difficulty in the field of
lung cancer treatment. In
traditional Chinese medicine(TCM),
angiogenesis is believed to fall into the category of “collateral
disease”. The invasion of external pathogens and
deficiency of healthy
Qi will cause visceral dysfunction, which can be gradually followed by
Qi obstruction and
blood stasis and phlegm-turbidity congesting the collaterals. As a result, the collateral function
will be damaged, providing favorable conditions for the occurrence of
lung cancer. More and more modern studies have confirmed that TCM is able to inhibit
angiogenesis in the
lung cancer, thereby resisting the
tumor. In addition, by
virtue of the unique advantages, TCM effectively reduces adverse reactions, enhances the
efficacy, and improves the
living conditions of
patients. Moreover, it can synergize with other western
medicine therapies in the
treatment of
lung cancer, exhibiting a wide application prospect. This
paper summarizes the mechanisms of TCM in inhibiting
angiogenesis of
lung cancer reported in relevant experimental
research, hoping to provide reference for the
optimization of clinical
treatment strategies for
lung cancer.