Radiotherapy is one of the most commonly used and effective
method to treat malignant
tumors in clinical practice. However, there are still some limitations including high
radiotherapy doses, harmful side effects on normal
tissues, and
radiation resistance of
tumor cells. Therefore, seeking safe and effective
radiotherapy sensitizers to improve
radiation sensitivity of
tumor cells has been focused for a long
time.
Histone deacetylase inhibitors (HDACIs), as a kind of
epigenetic modifiers, can regulate the
sensitivity of
tumor cells to
ionizing radiation and
ultraviolet radiation in addition to the inherent anticancer characteristics. This article reviewed the molecular mechanisms of HDACIs in enhancing
radiation sensitivity and by selectively
killing tumor cells.