Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group / Journal of the Korean Cancer Association, 대한암학회지
Kyung-Mi PARK; Keon-Hee YOO; Seong-Koo KIM; Jae-Wook LEE; Nack-Gyun CHUNG; Hee-Young JU; Hong-Hoe KOO; Chuhl-Joo LYU; Seung-Min HAN; Jung-Woo HAN; Jung-Yoon CHOI; Kyung-Taek HONG; Hyoung-Jin KANG; Hee-Young SHIN; Ho-Joon IM; Kyung-Nam KOH; Hyery KIM; Hoon KOOK; Hee-Jo BAEK; Bo-Ram KIM; Eu-Jeen YANG; Jae-Young LIM; Eun-Sil PARK; Eun-Jin CHOI; Sang-Kyu PARK; Jae-Min LEE; Ye-Jee SHIM; Ji-Yoon KIM; Ji-Kyoung PARK; Seom-Gim KONG; Young-Bae CHOI; Bin CHO; Young-Tak LIM.
Cancer Research and Treatment
; : 269-276, 2022.
Artículo
en Inglés
| WPRIM | ID: wpr-913833
Purpose@#Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. @*Materials and Methods@#Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. @*Results@#Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 10.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020). @*Conclusion@#This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.
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