We
report two cases of
patients with unresectable
pancreatic cancer treated with
neoadjuvant chemotherapy and surgical resection. In the first case, main mass was located at the
neck of the
pancreas, encasing
superior mesenteric artery and peritoneal seeding was suspected. In the second case, main mass was located at the body of
pancreas and
superior mesenteric artery was encased. Both
patients received FOLFIRINOX
chemotherapy regimen, consisting of
5-FU,
folinic acid,
irinotecan and
oxaliplatin. In both cases,
tumor size decreased and vascular involvement regressed in response to
chemotherapy. After subsequent chemoradiation
therapy, both
patients underwent surgical resection with negative
resection margin. The pathological stages were ypT1cN0 and ypT1aN0, respectively. Both
patients received postoperative
adjuvant chemotherapy with 6 cycles of
5-FU/
folinic acid and remained without evidence of
disease for more than 6 months after the
surgery.