OBJECTIVE To observe the
clinical efficacy and
safety of
albumin-bound paclitaxel combined with nedaplatin inductive
chemotherapy followed by
concurrent radiochemotherapy in the
treatment of loco-regionally advanced
nasopharyngeal carcinoma.
METHODS The clinical data of 45
patients (
observation group ) with loco-regionally advanced
nasopharyngeal carcinoma(Ⅲ/Ⅳa stage )
who received
albumin-bound paclitaxel combined with nedaplatin inductive
chemotherapy in our
hospital from August 2017 to July 2018 were retrospectively analyzed.
Propensity score was used to match 45
patients(
control group )with loco-regionally advanced
nasopharyngeal carcinoma who received
docetaxel combined with
cisplatin and
fluorouracil inductive
chemotherapy. After inductive
chemotherapy ,both groups received intensity-modulated
radiochemotherapy (IMRT);
observation group was additionally given concurrent nedaplatin
chemotherapy ,and
control groups was given concurrent
cisplatin chemotherapy.
Clinical efficacy and the
incidence of ADR were compared between 2 groups. RESULTS All
patients completed
treatment and 3-year follow-up. After inductive
chemotherapy and 1,3 months after
concurrent radiochemotherapy ,there was no statistical significance in short-term response between 2 groups(P>0.05). There was no significantly difference in 3-years local control rate and 3-years free from distant
metastasis between 2 groups(P>0.05). The
incidences of leucopenia (grade 3 or above )in the
observation group were significantly lower than those in the
control group ,and the
incidence of
peripheral neuropathy in
observation group was higher than that in
control group (P<0.05). The
incidences of
thrombocytopenia (grade 2 or above ),
rash and
vomiting (grade 2 or above )in the
observation group were lower than those in the
control group ,but the difference was not statistically significant (P>0.05). There was no significant difference in the
incidence of other ADR between 2 groups(P>0.05). CONCLUSIONS
Albumin-bound paclitaxel combined with nedaplatin inductive
chemotherapy followed by
concurrent chemoradiotherapy in the
treatment of loco-regionally advanced
nasopharyngeal carcinoma is effective and tolerable .