INTRODUCTION@#The use of novel
mRNA platforms for
COVID-19 vaccines raised concern about
vaccine safety, especially in
Asian populations that made up less than 10% of study
populations in the pivotal
vaccine trials used for
emergency use authorisation.
Vaccine safety issues also remain a concern in assessing the clinical
risks and benefits of
vaccine boosters, particularly in specific
age groups or segments of the
population. This study describes a
vaccination exercise involving
Asian military personnel, and the adverse reactions and
safety events observed.@*
METHODS@#
Minor adverse reactions, hospitalisations and adverse events of special interest were monitored as part of the organisation's protocol for
safety monitoring of COVID-19
vaccinations. All
vaccine recipients were invited to complete an online adverse reaction
questionnaire. Medical consults at the
military's
primary healthcare facilities were monitored for
vaccine-related presentations. All hospitalisations involving
vaccine recipients were analysed. Adverse reaction rates between doses,
vaccines and
age groups were compared.@*RESULTS@#A total of 127,081
mRNA vaccine doses were administered to 64,661 individuals up to 24 July 2021. Common
minor adverse reactions included
fever/
chills, body
aches and
injection site
pain. These were more common after
dose 2. Younger individuals experienced
minor adverse reactions more frequently. Rare cases of
anaphylaxis,
Bell's palsy and
myocarditis/
pericarditis were observed. No deaths occurred.@*CONCLUSION@#
Minor adverse reactions were less common than reported in other studies, and rates of
anaphylaxis,
Bell's palsy and
myocarditis/
pericarditis were comparable. Our study supports the favourable
safety profile of
mRNA COVID-19 vaccines, which may help guide decisions about booster doses if required.