Pancreatic cancer is one of the most aggressive
malignancies. The poor
prognosis of
pancreatic cancer patients is mainly attributed to low diagnostic rate at the early stage, highly aggressive
nature coupled with the inadequate
efficacy of current chemotherapeutic regimens. Novel
therapeutic strategies are urgently needed for
pancreatic cancer.
MicroRNAs (
miRNAs)
play an important regulatory
role in key processes of
cancer development. The aberrant expression of
miRNAs is often involved in the initiation, progression, and
metastasis of
pancreatic cancer. The discovery of
tumor suppressor
miRNAs provides prospects for the development of a novel
treatment strategy for
pancreatic cancer. We reviewed recent progress on the
understanding of the
role of
miRNAs in
pancreatic cancer, highlighted the efficient application of
miRNAs-based
therapies for
pancreatic cancer in
animal models and clinical trials, and proposed
future prospects. This
review focuses on the promise of integrating
miRNAs into the
treatment of
pancreatic cancer and provides guidance for the development of
precision medicine for
pancreatic cancer.