Objective@#The aim of this study was to explore the effects of 2-hexyl-4-pentylenic
acid (HPTA) in combination with
radiotherapy (RT) on distant unirradiated
breast tumors .@*
Methods @#Using a
rat model of chemical
carcinogen (7,12-dimethylbenz[a]anthracene,DMBA)-induced
breast cancer ,
tumor volume was monitored and
treatment response was evaluated by performing HE
staining ,
immunohistochemistry ,
immunofluorescence , qRT-
PCR , and
western blot analyses.@*Results@#The results demonstrated that HPTA in combination with RT significantly delayed the
growth of distant, unirradiated
breast tumors . The mechanism of action included
tumor-associated macrophage (TAM) infiltration into distant
tumor tissues , M1 polarization, and inhibition of
tumor angiogenesis by IFN-γ.@*Conclusion@#The results suggest that the combination of HPTA with RT has an abscopal effect on distant
tumors