OBJECTIVE@#To investigate the correlation of
platelet and coagulation function with
blood stasis
syndrome (BSS) in
coronary heart disease (CHD).@*
METHODS @#The protocol for this
meta-analysis was registered on PROSPERO (CRD42019129452).
PubMed , Excerpta Medica Database (Embase), the Cochrane
Library , and
China National
Knowledge Infrastructure (CNKI) were searched from inception to 1st June, 2020. Trials were considered eligible if they enrolled BSS and non-BSS (NBSS)
patients with CHD and provided information on
platelet and coagulation function. The
platelet function, coagulation function, and fibrinolytic activity were compared between the BSS and NBSS groups.
Forest plots were generated to show the SMDs or ESs with corresponding 95% CIs for each study. Subgroup
analysis and
sensitivity analysis were performed to explore potential sources of heterogeneity.@*RESULTS@#The systematic search identified 1,583 articles. Thirty trials involving 10,323
patients were included in the
meta-analysis . The results showed that
mean platelet volume ,
platelet distribution width,
platelet aggregation rate,
platelet P selectin ,
fibrinogen ,
plasminogen activator inhibitor -1 (
PAI-1 ),
thromboxane B2 (TXB2), 6-keto-
prostaglandin F1alpha (6-keto-PGF1 α), and TXB2/6-keto-PGF1 α were higher in the BSS group than in the NBSS group (P<0.05 or P<0.01).
Activated partial thromboplastin time was lower in the BSS group than in the NBSS group in the acute phase of CHD (P<0.01). The R and K values in
thromboelastography and
tissue plasminogen activator (t-PA) and t-PA/
PAI-1 were lower in the BSS group than in the NBSS group (all P<0.01). No difference was found in the results of
platelet count , plateletcrit, maximum amplitude,
von Willebrand factor ,
prothrombin time ,
thrombin time ,
international normalized ratio , etc. between groups.@*CONCLUSIONS@#Increased
platelet function,
hypercoagulability , and decreased fibrinolytic activity were found among CHD
patients with BSS.