Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis / 临床肝胆病杂志
Minghao LIU; Sutong LIU; Lihui ZHANG; Yajiao GU; Dongfang SHANG; Zhun XIAO; Wenxia ZHAO.
Journal of Clinical Hepatology
; (12): 1152-1155, 2022.
Artículo
en Zh
| WPRIM | ID: wpr-924797
Ferroptosis is a type of iron-dependent cell death driven by lipid peroxidation, and its mechanism is associated with iron homeostasis imbalance, lipid peroxidation, and slC7A11-GSH-GPX4 antioxidant system. Ferroptosis plays a key role in the development and progression of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), and inhibition of ferroptosis can almost completely inhibit the development of NASH. This article reviews the research advances in the mechanism of ferroptosis and its role in NAFLD/NASH and proposes the research strategies and technical means for ferroptosis, so as to provide a reference for research on the mechanism of NAFLD/NASH.
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WPRO
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