BACKGROUND/OBJECTIVES@#
Alzheimer's disease (AD) is one of the most representative
neurodegenerative disease mainly caused by the excessive
production of
amyloid beta (Aβ).Several studies on the
antioxidant activity and protective effects of
Populus tomentiglandulosa (PT) against
cerebral ischemia -induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against
cognitive impairment in AD.MATERIALS/
METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ 25–35-induced
mouse model and conducted behavioral experiments to test cognitive
ability . In addition, we evaluated the levels of
aspartate aminotransferase (AST) and
alanine aminotransferase (ALT) in
serum and measured the
production of
lipid peroxide ,
nitric oxide (NO), and
reactive oxygen species (ROS) in
tissues . @*RESULTS@#PT
treatment improved the space perceptive
ability in the T-
maze test , object cognitive
ability in the
novel object recognition test , and
spatial learning /
long-term memory in the Morris
water -
maze test . Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show
liver toxicity . Furthermore,
administration of PT significantly inhibited the
production of
lipid peroxide , NO, and ROS in the
brain ,
liver , and
kidney , suggesting that PT protected against
oxidative stress . @*CONCLUSIONS@#Our study demonstrated that
administration of PT improved Aβ25–35 -induced
cognitive impairment by regulating
oxidative stress . Therefore, we propose that PT could be used as a natural agent for AD improvement.