Co-amorphous technology to improve dissolution and physical stability of silybin / 中国中药杂志
Huan LIU; Guo-Wei ZHAO; Qie-Ying JIANG; Xin-Li LIANG; Liao-Qi OUYANG; Hai-Bo DING; Xu-Long CHEN; Zheng-Gen LIAO.
China Journal of Chinese Materia Medica
; (24): 103-110, 2022.
Artículo
en Zh
| WPRIM | ID: wpr-927916
The present study explored the effect of co-amorphous technology in improving the dissolution rate and stability of silybin based on the puerarin-silybin co-amorphous system prepared by the spray-drying method. Solid-state characterization was carried out by powder X-ray diffraction(PXRD), polarizing microscopy(PLM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC), etc. Saturated powder dissolution, intrinsic dissolution rate, moisture absorption, and stability were further investigated. The results showed that puerarin and silybin formed a co-amorphous system at a single glass transition temperature which was higher than that of any crude drug. The intrinsic dissolution rate and supersaturated powder dissolution of silybin in the co-amorphous system were higher than those of the crude drug and amorphous system. The co-amorphous system kept stable for as long as three months under the condition of 40 ℃, 75% relative humidity, which was longer than that of the single amorphous silybin. Therefore, the co-amorphous technology could significantly improve the dissolution and stability of silybin.
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