Fifty-seven SD rats were randomly(random number) divided into three groups sham operation group (SC group), cecal ligationpuncture induced septic ALI group (CLP group), and intraperitoneal administration of GM at 1 h after CLP (CLP-GM group). Twenty-four h after the experiment, the survival of rats in the SC, CLP and CLP-GM groups was observed, the lungtissue was collected for HE staining to observe the pathological changes, and the plasma was collected for metabonomicsdetection to analyze the characteristics of metabolites.