Objective: To explore the clinical application value of
limb remote
ischemic postconditioning (LRIPC) in
patients with acute
cerebral infarction after recanalization.
Methods: A total of 78
patients with acute
cerebral infarction admitted to the First Affiliated
Hospital of Shantou
University Medical College from June 2017 to March 2019 were selected. According to the random number table
method , they were divided into the
observation group with 39 cases (LRIPC + conventional medical
treatment ) and the
control group with 39 cases (conventional medical
treatment ). The
National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment scale (MoCA) scores, the changes of cerebral
blood perfusion ,
cerebral infarction volume and the levels of nerve function indexes before and after the
treatment were compared and analyzed.
Results: After the
treatment , the NIHSS scores in the
observation group were lower than thosein the
control group , and the MoCA scores were higher than those in the
control group , the differences were statistically significant ( P<0.05). After the
treatment , the mean transit
time of
cerebral blood flow in the
observation group was shorter than that in the
control group , while the
regional cerebral blood flow and regional
cerebral blood volume were higher than those in the
control group , the differences were statistically significant ( P<0.05). After the
treatment , the volume of
cerebral infarction in the
observation group was lower than that in the
control group ( P<0.05). After the
treatment , the levels of
matrix metalloproteinase 9 and
S-100B protein in the
observation group were lower than those in the
control group (142.45 ± 36.23) mg/L vs. (176.89 ± 42.63) mg/L, (2.52 ± 0.46) μg/L vs. (3.61 ± 0.75) μg/L; and the level of
nerve growth factor was higher than that in the
control group (143.49 ± 10.58) μg/L vs. (124.96 ± 13.62) μg/L, the differences were statistically significant ( P<0.05).
Conclusions: LRIPC can improve the nerve
functions, cognitive functions andreduce the volume of
cerebral infarction by improving
cerebral blood flow . It also has a good effect on alleviating the neurological functional impairment after vascular recanalization.