OBJECTIVE@#To explore the
incidence of
ischemic stroke after the onset of
type 2 diabetes, and further analyze the
risk factors, so as to provide a basis for further
research.@*
METHODS@#The data were obtained from the database of the
Beijing Urban
Employee Basic Medical
Insurance Database. The study used a prospective design to describe the
incidence of
ischemic stroke in
patients with
type 2 diabetes. In our study, these
patients were followed up for seven years. Multivariate
Logistic regression models were used to analyze the
risk factors of
ischemic stroke in
patients with
type 2 diabetes.@*RESULTS@#A total of 185 813 newly diagnosed
type 2 diabetes patients were enrolled, with an average age of (58.5±13.2) years, and 49.0% of them were
males. A total of 10 393
patients with newly diagnosed
ischemic stroke occurred in 7 years, with a
cumulative incidence of 5.6% and an
incidence density of 8.1/1 000
person-years.
Ischemic stroke occurred in all
age groups in
patients with
type 2 diabetes. The
cumulative incidence was 1.5% (95%CI 1.3%-1.6%) in group ≤44 years old, 3.6% (95%CI 3.4%-3.7%) in group 45-54 years old, 5.4% (95%CI 5.2%-5.5%) in group 55-64 years old, and 9.2% (95%CI 9.0%-9.4%) in group ≥65 years old, and the
cumulative incidence increased with age (P < 0.05).
Cumulative incidence rate of the
males (6.8%, 95%CI 6.7%-7.0%) was higher than the
females (4.4%, 95%CI 4.3%-4.6%). Among the
patients < 80 years old, the
cumulative incidence rate of the
males was higher than that of the
females in all the
age groups. In the
patients ≥80 years of age, the
cumulative incidence was higher in the
females (9.2%) than in the
males (7.9%). Further
analysis revealed that
complications, such as
coronary heart disease (OR=3.18, 95%CI 2.72-3.72),
heart failure (OR=1.53, 95%CI 1.32-1.79) and
kidney failure (OR=1.45, 95%CI 1.20-1.75) were associated with
ischemic stroke in the
patients with
type 2 diabetes.@*CONCLUSION@#The
incidence level of
ischemic stroke in
patients with
type 2 diabetes is high. It is necessary to strengthen the management of
risk factors in
elderly patients, screen the
complications of
type 2 diabetes as early as possible, and take active preventive and control
measures.