A
leukemoid reaction is usually associated with
malignancies of the
lung,
stomach, and
thyroid. In contrast, urothelial
cell carcinoma is rarely associated with
leukemoid reactions, with few cases reported over the past 30 years. Here, we describe a
patient with urothelial
cell carcinoma who exhibited a
leukemoid reaction. The
patient had an elevated
white blood cell count and experienced a rapid and aggressive
clinical course, terminating in
death. For urothelial
cell carcinoma patients exhibiting a
leukemoid reaction, removal of the inciting
tumor is the definitive
treatment. However, considering the aggressive
nature of these
tumors, if the
patient is unsuitable for radical surgical management, palliative
chemotherapy should be considered.