Zuojinwan originated from Danxi′s Experiential
Therapy (《丹溪心法》) in the Yuan dynasty. It is a representative
prescription for the
treatment of
liver fire invading
stomach syndrome, and is also one of the typical
prescriptions of the anti-adjuvant
method of
traditional Chinese medicine (TCM). In this
paper, the
method of
bibliometrics was used to systematically sort out the ancient
books of Zuojinwan, and 729 relevant
literature data were obtained. After certain retrieval and
screening, 57 ancient
books of TCM were finally obtained. The
statistics and
analysis were carried out from the aspects of
prescription source, historical evolution, composition, functions, evolution of
prescription meaning,
prescription dose, and preparation and usage of Zuojinwan. It was found that Zuojinwan was composed of
Coptis chinensis rhizoma and
Euodia rutaecarpa fructus in a ratio of 6∶1. It was mainly used for the
treatment of
liver fire invading
stomach syndrome. The symptoms included
pain in
chest and hypochondrium,
vomiting and bitter
mouth, noisy
acid-
swallowing, red
tongue coating yellow, and
pulse string number. Later
medical records recorded that Zuojinwan was mostly consistent with the original
prescription. It mainly treated various
diseases caused by
liver fire, including left by
liver fire, including left hypochondriac
pain,
swallowing acid and
vomiting acid,
tendon hernia and lump, epigastric
pain, bitter
mouth pulse string,
head pain,
diarrhea,
gonorrhea,
cold and hot,
abdominal pain, alcohol wet yellowing, silence of oral
dysentery and so on. There was little controversy in the
analysis of relevant
prescriptions. In the past dynasties, pills was mainly used, which was consistent with the original
prescription. In modern times, it is mainly
water flooding for pills or steamed cakes for pills, warm boiling
water to serve 6 g, taking 2-3 g per
time, the
history is basically the same. In this
paper, through the excavation, collation and systematic
analysis of the ancient
literature of TCM that recorded Zuojinwan, we
hope to provide the
literature basis for the development, inheritance and utilization of this famous classical formulas.