Diabetic nephropathy is one of the most common microvascular
complications of diabetes. It is the main cause of
end-stage renal disease and a cause of increased
mortality of diabetes. Moreover,
diabetic nephropathy has a complex pathogenesis, which is difficult to be detected in the early stage. Therefore, it is easy to miss the optimal intervention period in clinical
treatment, which seriously endangers the
life and
health of
patients. As an active ingredient of
Chinese medicine,
polysaccharides have
biological activities such as anti-
tumor, lowering
blood sugar, immune
regulation, anti-
oxidation and anti-
virus. In recent years, many studies have demonstrated that
polysaccharides in
Chinese medicine can effectively interfere with
diabetic nephropathy, with multi-target and multi-channel characteristics and significant effect, showing great potential. Although there are many studies on the mechanism of
Chinese medicine polysaccharides in the intervention of
diabetic nephropathy, there is a lack of a systematic and detailed
review on it. Therefore, based on the
animal experiments on the intervention of
Chinese medicine polysaccharides in
diabetic nephropathy in recent years, we analyzed and summarized the mechanism of
Chinese medicine polysaccharides in the intervention of
diabetic nephropathy from five aspects of improving
insulin resistance, improving
oxidative stress, reducing inflammatory reaction, protecting
kidney and improving
intestinal flora. In addition, the signaling pathways and
indicators involved in the mechanism were summarized, and the intervention effect and
polysaccharide structure
analysis were compared. The
paper was expected to provide a theoretical basis for the
basic research, new
drug development and clinical application of
Chinese medicine polysaccharides in the intervention of
diabetic nephropathy.