OBJECTIV E To develop the infor mation-based
pharmaceutical care pathway of
anticoagulant therapy in
patients with
atrial fibrillation and improve the
efficacy and
safety of
treatment for them.
METHODS The“
anticoagulant pharmaceutical care”module was developed on the basis of medical intelligent and
decision system.
Patients with
atrial fibrillation were taken
pharmaceutical care in the whole
anticoagulant treatment by evaluating the
thromboembolism and
bleeding risks ,pre-reviewing antithrombotic
prescriptions ,
monitoring efficacy and
drug interactions ,and
warning adverse reactions. RESULTS A total of 1 228
patients receiving
anticoagulant therapy were enrolled. It was found after
analysis of their doctor ’s orders that 9.27% of the
patients adjusted the improper antithrombotic
therapies ,3.99% modulated
treatments according to the effects of potential
drug interactions or the
risk of adverse reactions ,and 70.29% of the wrong
prescriptions were intervened successfully. After the information-based
pharmaceutical care ,the anticoagulation
treatment rate increased from 88.73% to 97.40%,the rate of
patients ’
achievements to
warfarin’s
international normalized ratio in
hospital increased from 38.64% to 66.67%,and the
incidence of serious
bleeding events decreased from 2.94% to 0.37% (P<0.05). CONCLUSIONS The information-based
pharmaceutical care path of
anticoagulant therapy achieved comprehensive ,efficient and accurate management of
patients with
atrial fibrillation ,and improved the rationality ,
effectiveness and
safety of
anticoagulant therapy.