DNA methylation, as an important form of
epigenetic modification,
plays vital
roles in the occurrence and development of
diseases by regulating
gene expression. In recent years, with the rapid development of
DNA methylation research and the continuous updates of the
detection method,it is reported that
DNA methylation has become an important way to explore the pathogenesis of various
diseases and new
treatment methods.Many breakthroughs have been made in the
basic research of
DNA methylation in different ophthalmological
diseases, including
corneal epithelium repair,
cell adhesion and abnormal matrix
remodeling of conjunctival
epithelium, ocular
fibrosis and
glaucoma,
oxidative stress, inflammatory response and
cell damage, the relationship between different
DNA methylation levels and ocular
tumors, etc. This
review aims to provide a new idea for the pathogenesis, examination,
diagnosis and prevention of different ocular
diseases by summarizing the relevant studies on the regulatory mechanisms of
DNA methylation in ophthalmological
diseases.