MicroRNA-126 inhibits the proliferation of lung cancer cell line A549

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Xun YANG; Bei-Bei CHEN; Ming-Hua ZHANG; Xin-Rong WANG.

Asian Pacific Journal of Tropical Medicine ; (12): 239-242, 2015.

Artículo en Zh | WPRIM | ID: wpr-951529

Objective:

To study the role of microRNA-126 in the development of lung cancer.

The biological function of microRNA-126 was detected using EdU assay and CCK-8 assay; the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay.

In A549 cell line, overexpression of microRNA-126 inhibits the proliferation rate; VEGF is the target gene of microRNA-126; microRNA-126 exerts its function via regulating VEGF protein level.

microRNA-126 inhibits the proliferation in A549 cell line.

Biblioteca responsable: WPRO