Objective: To study the clinical characteristics of neonatal
community -acquired Novel
Coronavirus (COVID-19) Omicron variant
infection .
Methods: From March 30 to May 15, 2022, the epidemiological characteristics, clinical manifestations and outcomes of neonatal cases of
community -acquired COVID-19 Omicron variant
infection admitted to the isolation ward of our
hospital were analyzed.
Results: A total of 7
neonates infected with
community -acquired COVID-19 Omicron variant were treated, including 3
males and 4
females . All of them were term
infants with clear epidemiological exposure
history . The
infection was originated from
caregivers of close contact (
parents or babysitters). The main clinical symptoms was
upper respiratory tract infection , including
fever (6 cases), nasal congestion (6 cases),
cough (5 cases),
runny nose (2 cases), poor
appetite (2 cases) and
diarrhea (1 case). On admission, no
abnormalities were found in
blood routine examination and
C-reactive protein (CRP). All but one case had normal
serum amyloid A (SAA). No obvious
abnormalities were found on
chest X-ray . All
patients were isolated in single-
patient rooms after admission. They received standard symptomatic
treatment and regular
nucleic acid tests. The first negative
nucleic acid results came on median 17 d(8~26 d) after the onset of the
disease . The
patients were discharged after two consecutive (24 h apart)
nucleic acid tests with CT value ≥35 and continued
health -monitor at home. On discharge, 5
patients had nasal congestion and 2 of them had
cough . During the follow-up 4~6 weeks after discharge, all
patients gradually recovered without positive
nucleic acid results.
Conclusions: All 7
neonates with
community -acquired COVID-19 Omicron variant
infection have epidemiological exposure
history . The main clinical symptoms are long-lasting
upper respiratory tract infections . It takes a relatively long
time for the
nucleic acid to turn negative, however, the overall short-term
prognosis is good.