Diabetes mellitus is a chronic
metabolic disease, in which the abnormality of
glucose and
lipid metabolism may cause multisystem damage.
Sodium-
glucose synergistic transporter 2 (SGLT2) inhibitors are a novel type of
hypoglycemic drug that can lower
blood sugar level by inhibiting the
absorption of
glucose through renal tubules. Studies have shown that
SGLT2 inhibitors also have a lowering effect on
blood pressure, but the mechanism is not fully elucidated. In this article the hypotensive effects of
SGLT2 inhibitors and possible mechanisms are reviewed.