Objective @#To explore the prognostic value of
chemoradiotherapy based on the depth of invasion (DOI) in
patients with
oral squamous cell carcinoma.@*
Methods @#
Patients with
oral squamous cell carcinoma who received surgical
treatment in a
hospital from 2008 to 2016 were enrolled. The
chi-square test was used to compare the effects of DOI on postoperative cervical
lymph node metastasis and local
recurrence. The effects of
chemoradiotherapy on postoperative cervical
lymph node metastasis, local
recurrence, and
survival were analyzed based on the DOI.@*Results@# A total of 111
patients with
oral squamous cell carcinoma were included in this study. The postoperative local
recurrence rate (P<0.05) and cervical
lymph node metastasis rate (P<0.05) of
patients with 5 mm < DOI ≤ 10 mm and DOI > 10 mm were significantly higher than those with DOI ≤ 5 mm. The
time of postoperative
recurrence was concentrated within two years after the operation. The greater the DOI was, the shorter the
time to postoperative
recurrence (P<0.05). The addition of postoperative
chemoradiotherapy did not significantly improve the postoperative local
recurrence rate, cervical
lymph node metastasis or
survival rate of
patients with different DOIs (P > 0.05). @*Conclusion@#DOI has important predictive value for postoperative
recurrence, cervical
lymph node metastasis and
survival rate. However, DOI cannot be used as an independent index to guide whether
chemoradiotherapy is needed after
oral cancer surgery.