OBJECTIVE:
To elucidate the
association between
glycemic control status and clinical outcomes in
patients with
acute ischemic stroke limited to the deep branch of the
middle cerebral artery (MCA).
METHODS:
We evaluated 65 subjects with first-ever
ischemic stroke of the deep branches of the MCA, which was confirmed by
magnetic resonance angiography. All subjects had
blood hemoglobin A1c (HbA1c) measured at admission. They were classified into two groups according to the level of HbA1c (low or =7.0%). Neurological impairment and
functional status were evaluated using the
National Institutes of Health Stroke Scale (NIHSS),
Functional Independence Measure (FIM), Korean version of Modified Barthel Index (K-MBI), Korean version of Mini-Mental
State Examination (MMSE-K), and the Loewenstein
Occupational Therapy Cognitive Assessment (LOTCA) at admission and discharge.
Body mass index,
serum glucose,
homocysteine and
cholesterol levels were also measured at admission.
RESULTS:
The two groups did not show any difference in the NIHSS, FIM, K-MBI, MMSE-K, and LOTCA scores at any
time point.
Body mass index and levels of
blood homocysteine and
cholesterol were not different between the two groups. The
serum blood glucose level at admission was negatively correlated with all
outcome measures.
CONCLUSION:
We found that HbA1c cannot be used for predication of clinical outcome in
patients with
ischemic stroke of the deep branch of the
middle cerebral artery.