Urinefluoride concentration in the contact group was correlated with creatinine-adjusted urinefluoride concentration (r=0.69, P=0.001). There was no significant correlation between the external dose of hydrogen fluoride and urinefluoride in the contact group (r=0.03, P=0.132). The concentrations of urinefluoride in the contact group and the control group were (0.81±0.61) and (0.45±0.14) mg/L, respectively, and the difference between the two groups was statistically significant (t=5.01, P=0.025). Using BGP, AKP and HYP as effect indexes, the urinary BMDL-05 values were 1.28, 1.47 and 1.08 mg/L, respectively.
Conclusion:
Urinary fluoride can sensitively reflect the changes in the effect indexes of biochemical indexes of bonemetabolism. BGP and HYP can be used as early sensitive effect indexes of occupational hydrogen fluoride exposure.