Atomoxetine is the first non-stimulant
drug for the
treatment of
children and
adults with
attention deficit hyperactivity disorder (
ADHD ), and its
safety and
efficacy show significant differences in the pediatric
population . This article reviews the genetic factors influencing the pharmacokinetic differences of
atomoxetine from the aspect of the
gene polymorphisms of the major metabolizing
enzyme CYP2D6 of
atomoxetine , and then from the perspective of
therapeutic drug monitoring , this article summarizes the
reference ranges of the effective concentration of
atomoxetine in
children with
ADHD proposed by several studies. In general, there is an
association between the peak
plasma concentration of
atomoxetine and
clinical efficacy , but with a lack of data from the
Chinese pediatric
population . Therefore, it is necessary to establish related clinical
indicators for
atomoxetine exposure, define the
therapeutic exposure range of
children with
ADHD in
China , and combine
CYP2D6 genotyping to provide support for the precision medication of
atomoxetine .