OBJECTIVE@#To investigate the causes of
graft loss in
kidney transplant recipients.@*
METHODS@#We retrospectively analyzed the clinical data of 135 recipients with
graft loss after
renal transplantation in the Eighth Medical Center of
Chinese PLA
General Hospital from January 1, 2002 to January 1, 2022.@*RESULTS@#A total of 135
kidney transplant recipients experienced
graft failure. The causes of
graft loss included
graft rejection (70 cases, 51.8%),
death of the recipients with functional
graft (37 cases, 27.4%), surgical
complications (12 cases, 8.9%),
drug toxicity (4 cases, 3.0%),
carbapenem-resistant
Klebsiella pneumoniae infection (4 cases, 3.0%), polyoma
BK virus-related nephropathy (3 cases, 2.2%), primary nonfunctioning
kidney (2 cases, 1.5%),
recurrence of primary
disease (2 cases, 1.5%), and prerenal
acute renal failure (1 case, 0.7%).@*CONCLUSION@#The main cause of
graft loss after
renal transplantation is
graft rejection, and the
secondary cause is
death of the recipient with functional
graft, and other reasons can be rare.