@#Objective , To investigate the
role of
serum chemokines and oxidative and
antioxidant biomarkers in occupational (
silicosis)
Methods silicosis hereinafter referred to as . A total of 58
patients with stage Ⅰ
silicosis were selected as the - ( ),
research subjects using convenient sampling
method. The
serum levels of nuclear factor erythroid 2 related factor 2 Nrf2 -( - ) - ( - - ) -
heme oxygenase 1 HO 1 and 8 isoprstaglandin F2α 8 iso
PGF2α were determined by
enzyme linked immunesorbent assay. ( ) ( - ) The
serum levels of
lipid peroxide LPO and total
antioxidant capacity TAOC were determined by
chemistry colorimetric
method. - - ( - ), Luminex flow
fluorescence technology was used to detect the
serum levels of
interferon γ inducible protein10 IP10
macrophage ( )- , - - ( ) inflammatory
protein MIP 1α MIP1β and macrophagederived
chemokine MDC . The above
indicators were analyzed by factor Results -
analysis. The information extraction rate of the original
indicators of the nine
biomarkers was 58.5%96.5%. Four common , , ( ) , factors were extracted including Nrf2
antioxidant signaling pathway
helper T cell Th 1 dominant
chemotaxis the total , , , , ,
oxidation/
antioxidant balance and Th2 dominant
chemotaxis whose variance contribution rates were 32.2% 19.1% 16.4% , , Conclusion - and 11.8% respectively and the cumulative variance contribution rate was 79.5%. Both the
oxidant antioxidant , disturbance and the dominance
chemotaxis are involved in the occurrence and development of
silicosis and the Nrf2
antioxidant signaling pathway
plays the most critical
role.