Background@#There are several differences in the
clinical course of
hypertension due to the
biological and social differences between
men and
women. Resistant
hypertension is an advanced
disease state, and significant
gender difference could be expected, but much has not been revealed yet. The purpose of this study was to compare
gender differences on the current status of
blood pressure (BP) control and clinical
prognosis in
patients with resistant
hypertension. @*
Methods@#This is a multicenter, retrospective
cohort study using common data model databases of 3
tertiary hospitals in
Korea. Total 4,926
patients with resistant
hypertension were selected from January 2017 to December 2018. Occurrence of
dialysis,
heart failure (HF)
hospitalization,
myocardial infarction,
stroke,
dementia or all-cause
mortality was followed up for 3 years. @*Results@#
Male patients with resistant
hypertension were younger but had a higher
cardiovascular risk than
female patients.
Prevalence of
left ventricular hypertrophy and
proteinuria was higher in
men than in
women. On-
treatment diastolic BP was lower in
women than in
men and target BP
achievement rate was higher in
women than in
men.During 3 years, the
incidence of
dialysis and
myocardial infarction was higher in
men, and the
incidence of
stroke and
dementia was higher in
women. After
adjustment,
male sex was an independent
risk factor for HF
hospitalization,
myocardial infarction, and all-cause
death. @*Conclusion@#In resistant
hypertension,
men were younger than
women, but end-organ damage was more common and the
risk of cardiovascular event was higher. More intensive cardiovascular prevention
strategies may be required in
male patients with resistant
hypertension.